Reliable Online Purchase of  Methadose

What is methadone?

Methadone is a long-acting opioid medication that is used to reduce withdrawal symptoms in people addicted to heroin or other narcotic drugs, and it can also be used as a pain reliever.

Methadone for Opioid Use Disorder (OUD) helps to reduce withdrawal symptoms and drug cravings without causing the “high” associated with drug addiction. Methadone is a highly regulated medication (Schedule 2 Controlled Substances Act) and, when used for OUD, it is only available through approved opioid treatment programs (OTP) that involve regular monitoring, counseling, and drug testing to make sure that patients are making progress in their recovery.

Methadone is used for severe and persistent pain that can not be treated effectively with other pain medications, including immediate-release opioids.

Methadone works by activating the opioid receptors in the brain and nervous system. It is usually taken orally as a liquid or tablet.

What is methadone FDA-approved for?

Management of severe, persistent pain

• For patients who require an opioid analgesic
• For those for whom alternative treatment options are inadequate, including immediate-release opioids
• Limitations of use (for pain).
  • Due to the risks of addiction, abuse, misuse, overdose, and death, methadone should be reserved for patients in whom:
    • Alternative treatment options are ineffective
    • Alternative treatment options are not tolerated
    • Alternative treatment options are otherwise inadequate to provide sufficient pain management
  • Not indicated for as-needed (PRN) analgesic use

Detoxification treatment of opioid addiction

• For dependence on heroin or other morphine-like drugs

Maintenance treatment of opioid addiction

• For dependence on heroin or other morphine-like drugs
• To be used in conjunction with appropriate medical and social services
• FDA limitations for opioid addiction treatment in detoxification or maintenance programs:
  • Use is subject to the federal conditions for distribution and administration under 42 CFR 8.12

Boxed Warning

Methadone has a boxed warning for serious and life-threatening harm. A boxed warning is the strongest safety-related warning issued by the FDA.

Addiction, misuse, and overdose
Methadone is an opioid. It can be addictive and can be misused or abused. This can lead to overdose or death. Your healthcare provider should check your risk before prescribing it and monitor you regularly while you take it.

Dangerously slow or stopped breathing
Methadone can cause breathing problems that may be severe or fatal, especially when you first start taking it or when your dose is increased. Taking the right dose exactly as prescribed is very important.

Accidental use
Taking even one dose by accident, especially by a child, can cause a fatal overdose.

Mixing with certain medicines or alcohol
Taking methadone with benzodiazepines, alcohol, or other drugs that make you sleepy or slow your breathing can cause extreme drowsiness, breathing problems, coma, or death. These combinations should only be used when other treatment options are not good enough.

Pregnancy and newborn withdrawal
If methadone is used during pregnancy, the baby may be born with opioid withdrawal symptoms called
Neonatal Opioid Withdrawal Syndrome (NOWS). This condition can be serious or life-threatening if it is not recognized and treated. Patients should be told about this risk so the baby can be monitored and treated if needed.

Opioid REMS Patient education
Healthcare providers are strongly encouraged to complete a Risk Evaluation and Mitigation Strategy (REMS) compliant education program. Healthcare providers are encouraged to educate patients and caregivers about the serious risks of methadone, how to use it safely, and the importance of reading the Medication Guide every time it is prescribed.

Heart rhythm problems
Methadone can cause serious changes in heart rhythm, including a dangerous condition that can be life-threatening. The risk may be higher in people with certain heart problems, people taking higher doses, or people taking other medicines that affect the heart. Careful monitoring may be needed, especially when starting treatment or changing the dose.

Drug interactions
Many medicines can change how methadose works in your body. Some can raise methadose levels and increase the risk of severe sleepiness, breathing problems, or death. Stopping certain medicines can also raise methadone levels. Your healthcare provider should monitor you closely and may need to adjust your dose if your other medicines change.

Use for opioid addiction treatment
When methadose is used to treat opioid addiction, it must be given under strict federal treatment rules. These rules include limits on when doses can be taken without supervision.

Important information

• Get emergency help or call 911 right away if you take too many Dolophine hydrochloride tablets (overdose). When you first start taking
• Dolophine
• hydrochloride tablets, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Ask your healthcare provider about medicines like naloxone or nalmefene that can be used in an emergency to reverse an opioid overdose, a medicine for the emergency treatment of an opioid overdose.
• Taking methadone hydrochloride tablets with other opioid medicines, benzodiazepines, gabapentinoids (gabapentin or pregabalin), alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death.
• Methadone-associated hypoglycemia (low blood sugar levels) has been reported in patients using this medicine, some resulting in hospitalization. In many cases, patients had predisposing risk factors such as diabetes.
• Never give anyone else your methadone hydrochloride tablets. They could die from taking it. Selling or giving away methadone hydrochloride tablets is against the law.
• Store methadone hydrochloride tablets securely, out of sight and reach of children, and in a location not accessible by others, including visitors to the home.