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Occurring more frequently in the U.S., heroin purchased on the street may be “cut” or contaminated with other dangerous and extremely potent opioids, such as fentanyl or carfentanyl. These agents are often fatal to the user, and deaths have been reported.
How can a heroin overdose be treated?
Naloxone is a medicine that can treat an opioid overdose when given right away. It works by rapidly binding to opioid receptors pure heroin and blocking the effects of heroin and other opioid drugs. Sometimes more than one dose may be needed to help a person start breathing again, which is why it’s important to get the person to an emergency department or a doctor to receive additional support if needed .
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Formulation-Specific Side Effects
Injectable Fentanyl (IV/IM), such as Sublimaze
The most common serious adverse reactions are respiratory depression, apnea, rigidity, and bradycardia. Other reported effects include hypertension, hypotension, dizziness, blurred vision, nausea, vomiting, diaphoresis, pruritus, urticaria, laryngospasm, and anaphylaxis
Fentanyl Transdermal Patch
Possible side effects of the fentanyl transdermal patch (eg, Duragesic) include respiratory depression, sedation, constipation, nausea, and skin reactions at the application site.
Exposure of the application site to direct external heat sources has resulted in fatal overdose, as heat significantly increases fentanyl absorption.
Fentanyl Oral Transmucosal Lozenge (OTFC)
Fentanyl OTFC (eg, Actiq) contains sugar. Cavities and tooth decay can happen in people taking OTFC. When taking OTFC, you should talk to your dentist about proper care of your teeth.
Possible side effects are similar to other transmucosal formulations and include respiratory depression, sedation, nausea, dizziness, and oral mucosal irritation.
Fentany Buccal Tablet
The possible side effects of fentany buccal or sublingual tablets (eg, Fentora) are similar to other transmucosal formulations, such as respiratory depression, nausea, dizziness, and headache.
Fentany Nasal Spray
The possible side effects of fentany nasal spray include respiratory depression, nasal irritation, nausea, dizziness, and somnolence.
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