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Warnings

You should not take morphine if you have severe asthma or breathing problems, a blockage in your stomach or intestines, or a bowel obstruction called paralytic ileus.

Morphine can slow or stop your breathing and may be habit-forming. MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Keep the medication in a place where others cannot get to it.

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use morphine with alcohol or with other drugs that cause drowsiness or slow your breathing.

Before taking this medicine

You should not take this medicine if you have ever had an allergic reaction to morphine or other opioid medicines or if you have:

  • severe asthma or breathing problems;
  • a stomach or bowel obstruction (including paralytic ileus); or
  • if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.
To make sure morphine is safe for you, tell your doctor if you have ever had:
  • chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder;
  • a head injury, brain tumor, high pressure inside the skull, or seizures;
  • a drug or alcohol addiction or mental illness;
  • urination problems;
  • problems with your bile duct, gallbladder, pancreas, thyroid, or adrenal gland; or
  • liver or kidney disease.

Tell your doctor if you also use stimulant medicine, other opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with morphine could cause a serious condition called serotonin syndrome.

Pregnancy

Kadian may harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. If you use Kadian during pregnancy, your baby could be born with life-threatening withdrawal symptoms and may need medical treatment for several weeks.

Long-term Kadian use may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.

Breastfeeding

Do not breastfeed when using  Kadian, as morphine in breast milk can cause life-threatening side effects in a nursing baby.