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Formulation-Specific Side Effects

Injectable Fentanyl (IV/IM), such as Sublimaze

The most common serious adverse reactions are respiratory depression, apnea, rigidity, and bradycardia. Other reported effects include hypertension, hypotension, dizziness, blurred vision, nausea, vomiting, diaphoresis, pruritus, urticaria, laryngospasm, and anaphylaxis

Fentanyl Transdermal Patch

Possible side effects of the fentanyl transdermal patch (eg, Duragesic) include respiratory depression, sedation, constipation, nausea, and skin reactions at the application site.

Exposure of the application site to direct external heat sources has resulted in fatal overdose, as heat significantly increases fentanyl absorption.

Fentanyl Oral Transmucosal Lozenge (OTFC)

Fentanyl OTFC (eg, Actiq) contains sugar. Cavities and tooth decay can happen in people taking OTFC. When taking OTFC, you should talk to your dentist about proper care of your teeth.

Possible side effects are similar to other transmucosal formulations and include respiratory depression, sedation, nausea, dizziness, and oral mucosal irritation.

Fentany Buccal Tablet

The possible side effects of fentany buccal or sublingual tablets (eg, Fentora) are similar to other transmucosal formulations, such as respiratory depression, nausea, dizziness, and headache.

Fentany Nasal Spray

The possible side effects of fentany nasal spray include respiratory depression, nasal irritation, nausea, dizziness, and somnolence.

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