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Uses

Fentanyl is used to manage breakthrough pain in adults and adolescents 16 years of age and older with cancer who are already routinely taking other opioid pain medicines around-the-clock for cancer pain.

• Oral transmucosal fentany preparations or fentany nasal spray are not for treating pain that is not cancer-related, such as migraine headaches or pain after surgery.

Fentany skin patches may be used when other pain treatments, such as non-opioid pain medicines or immediate-release opioid medicines, do not treat your pain well enough or you cannot tolerate them.

Fentany injection is used as a short-acting analgesic before, during, and after surgery and for anesthesia support in general or regional anesthesia or high-risk patients.

Fentany is a strong prescription opioid pain medicine that is started only after you have been taking other opioid pain medicines and your body has become used to them (you are opioid tolerant). Do not use fentany if you are not opioid tolerant.

An opioid pain medicine that can put you at risk for overdose and death. Even if you take your dose correctly as prescribed, you are at risk for opioid addiction, abuse, and misuse that can lead to death. pure fentanyl powder

Fentany was first developed in 1959 and received its initial FDA approval on February 19, 1968. It is a prescription medicine classified as a Schedule II controlled substance under the Controlled Substances Act (CSA).

Fentany sublingual sprays, sublingual/buccal tablets, nasal sprays, and transmucosal lozenges have been discontinued (both branded and generic versions).

• Fentany is only available as an injection and a transdermal patch.

Important Information About Fentany

Because of the risks of addiction, abuse, and misuse, overdose, and death with opioids, which can occur at any dosage or duration and persist over the course of therapy, reserve:

• Transdermal fentany for use when other pain treatments, such as non-opioid pain medicines or immediate-release opioid medicines, do not treat pain well enough or are not tolerated
• Transmucosal and nasal fentany for use in cancer patients for whom alternative treatment options (such as non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.

Get emergency help or call 911 right away if you take too much fentany (overdose). When you first start taking fentanyl, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Ask your healthcare provider about medicines like naloxone or nalmefene that can be used in an emergency to reverse an opioid overdose.

Taking fentany with other medicines that may make you sleepy, such as other pain medicines, gabapentinoids (gabapentin or pregabalin), antidepressants, sleeping pills, anti-anxiety medicines, antihistamines, or tranquilizers, or with alcohol or street drugs can cause severe drowsiness, confusion, breathing problems, coma, and death.

Never give anyone else your fentanyl. They could die from taking it. Selling or giving away fentanyl is against the law.

Store fentany securely, out of sight and reach of children, and in a location not accessible by others, including visitors to the home.

If you stop taking your around-the-clock opioid pain medicine for your cancer pain, you must stop using fentany. You may no longer be opioid tolerant. Talk to your healthcare provider about how to treat your pain.

Why is Fentany so Dangerous?

Fentany is a powerful synthetic opioid, 100 times stronger than morphine, legally used for severe pain but widely misused. If you have been prescribed fentanyl, take your dose exactly as your healthcare provider tells you to take it. Even patients who have been prescribed fentanyl at the correct dose are at risk of overdose, as the margin between a therapeutic and a fatal dose is narrow.

Illegally manufactured fentanyl (IMF) is frequently mixed into street drugs like heroin and cocaine, often without users’ knowledge, making it extremely dangerous. IMF comes in powder, liquid, pills, and even candy form, posing risks to children. Just 2-3 mg can cause fatal respiratory depression.

In 2025, over 76,000 Americans died from fentanyl overdoses. Overdose signs include pinpoint pupils, slow breathing, and loss of consciousness, but are treatable with naloxone (Narcan) if given promptly. Withdrawal symptoms include nausea, anxiety, and muscle pain.

Side Effects

The possible side effects of Fentany are constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, abdominal pain, weakness, anxiety, depression, rash, and trouble sleeping. Call your healthcare provider if you have any of these symptoms and they are severe.

Fentany may also decrease your blood pressure. This can make you feel dizzy or lightheaded if you get up too fast from sitting or lying down.

Get emergency medical help or call 911 right away if you have:

• Trouble breathing or shortness of breath
• Fast heartbeat or chest pain
• Swelling of your face, tongue, or throat
• Extreme drowsiness
• Light-headedness when changing positions or feeling faint
• Agitation
• High body temperature
• Trouble walking
• Stiff muscles
• Mental changes such as confusion

These symptoms can be a sign that you have used too much fentany or that the dose is too high for you. These symptoms may lead to serious problems or death if not treated right away. If you have any of these symptoms, do not use any more fentany until you have talked to your healthcare provider.

These are not all the possible side effects of fentany. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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